Application of long-circulating liposomes to cancer photodynamic therapy.

  title={Application of long-circulating liposomes to cancer photodynamic therapy.},
  author={Naoto Oku and Naoki Saito and Yukihiro Namba and Hideo Tsukada and David H. Dolphin and Shoji Okada},
  journal={Biological & pharmaceutical bulletin},
  volume={20 6},
Photodynamic therapy (PDT) as a cancer treatment is notable for its quite low side effects in comparison with those of chemotherapy and radiotherapy. However, the accumulation of porphyrin derivatives used in PDT into tumor tissues is rather low. Since long-circulating liposomes are known to accumulate passively into tumor tissues, we liposomalized a porphyrin derivative, benzoporphyrin derivative monoacid ring A (BPD-MA), and used these liposomes to investigate the usefulness of PDT for tumor… CONTINUE READING
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