Application of logistic regression to case-control association studies involving two causative loci.

@article{North2005ApplicationOL,
  title={Application of logistic regression to case-control association studies involving two causative loci.},
  author={Bernard V. North and David Curtis and Pak C. Sham},
  journal={Human heredity},
  year={2005},
  volume={59 2},
  pages={79-87}
}
Models in which two susceptibility loci jointly influence the risk of developing disease can be explored using logistic regression analysis. Comparison of likelihoods of models incorporating different sets of disease model parameters allows inferences to be drawn regarding the nature of the joint effect of the loci. We have simulated case-control samples generated assuming different two-locus models and then analysed them using logistic regression. We show that this method is practicable and… CONTINUE READING

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