Application of lag‐time into exposure definitions to control for protopathic bias

  title={Application of lag‐time into exposure definitions to control for protopathic bias},
  author={Hani Tamim and Amir Abbas Tahami Monfared and Jacques LeLorier},
  journal={Pharmacoepidemiology and Drug Safety},
To control for protopathic bias, some studies have incorporated the concept of lag‐time into their exposure definition (time period before the index date that was not considered in assessing exposure). The objective of this study was to introduce a procedure to identify the best lag‐time to be applied in studies where control for protopathic bias is required. 
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