Application of interleukin-2–secreting syngeneic/allogeneic fibroblasts in the treatment of primary and metastatic brain tumors

Abstract

We found previously that mice injected intracerebrally (i.c.) with a mixture of malignant cells and allogeneic fibroblasts genetically engineered to secrete interleukin-2 (IL-2) survived longer than mice in various control groups. The primary goal of this study was to determine if an established i.c. glioma (Gl261) or breast carcinoma (SB-5b) could be… (More)
DOI: 10.1038/sj.cgt.7700459

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