Application of in vitro-in vivo correlations (IVIVC) in setting formulation release specifications.

@article{Modi2000ApplicationOI,
  title={Application of in vitro-in vivo correlations (IVIVC) in setting formulation release specifications.},
  author={Nishit B Modi and Andrew Ting-Ho Lam and Elizabeth Lindemulder and B-J Wang and Suneel K. Gupta},
  journal={Biopharmaceutics & drug disposition},
  year={2000},
  volume={21 8},
  pages={321-6}
}
An in vitro-in vivo correlation (IVIVC) was established for an osmotic controlled-release dosage form by deconvolution using data from an immediate-release treatment as the characteristic response. The established IVIVC was evaluated internally (predicting data used to develop the IVIVC) and externally (predicting data not originally included in developing the IVIVC), and the application of the IVIVC in product development was demonstrated. The estimated in vivo dissolution profile compared… CONTINUE READING