Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY.

@article{Ma2009ApplicationOH,
  title={Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY.},
  author={Y. Ma and L. Lang and L. Reyes and Joji Tokugawa and E. Jagoda and D. Kiesewetter},
  journal={Nuclear medicine and biology},
  year={2009},
  volume={36 4},
  pages={
          389-93
        }
}
  • Y. Ma, L. Lang, +3 authors D. Kiesewetter
  • Published 2009
  • Chemistry, Medicine
  • Nuclear medicine and biology
  • High-sensitivity and high-resolution LC/MS instrumentation has been applied in positron emission tomography (PET) radiopharmaceutical development to provide quantitative measurement of the mass of radiotracers extracted from tissues of rats. We employed the highly sensitive Waters Q-TOF premier MS coupled with an Acquity UPLC system to demonstrate that LC-MS can generate ex vivo biodistribution data for PET 5-HT(1A) ligand FPWAY without the need to radiolabel. For the biodistribution studies… CONTINUE READING
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