Application of fluorescence in situ hybridization in hematological disorders.

@article{Chen1992ApplicationOF,
  title={Application of fluorescence in situ hybridization in hematological disorders.},
  author={Zhong Chen and Rod Morgan and C. S. Berger and Avery A. Sandberg},
  journal={Cancer genetics and cytogenetics},
  year={1992},
  volume={63 1},
  pages={62-9}
}
In the present study, chromosome changes in bone marrow (BM) or peripheral blood (PB) cells from 13 patients with malignant hematologic disorders were analyzed by classical cytogenetic techniques (G-banding) and fluorescence in situ hybridization (FISH) procedures using centromere specific probes for chromosomes 1, 6, 7, 8, 9, 12, 18, 13/21, and X, and a DNA probe specific for the long arm of chromosome Y. The cytogenetic data obtained with G-banding were in accord with those obtained by FISH… CONTINUE READING