Application of ferrocene and its derivatives in cancer research

  title={Application of ferrocene and its derivatives in cancer research},
  author={Catia Ornelas},
  journal={New Journal of Chemistry},
  • C. Ornelas
  • Published 26 September 2011
  • Chemistry
  • New Journal of Chemistry
The use of ferrocene-based compounds for medicinal applications is an active research area. Many reports have demonstrated that some ferrocenyl derivatives are highly active against several diseases, including cancer. This review focuses on the most relevant examples of ferrocene-based molecules that show anticancer activity. 

The medicinal chemistry of ferrocene and its derivatives

The unique properties of ferrocene-containing compounds make them useful for treating many diseases. The most notable drug candidates — the antimalarial ferroquine and the anticancer agent ferrocifen

Ferrocenes as potential anticancer drugs. Facts and hypotheses

We analyzed the research data on antitumor effects of a wide range of ferrocene compounds and discussed possible mechanisms of their bioactivities. Current trends in the study of anticancer effects

Ferrocene modification of organic compounds for medicinal applications

The results of the authors on the synthesis of ferrocene-containing organic compounds obtained in 1998–2013 are summarized. The review is focused on the ferrocene modifications of purine and

Electrochemical analysis of a novel ferrocene derivative as a potential antitumor drug.

This work determined an uptake of a novel ferrocene derivative in low μM concentrations by selected cancer cell lines and showed its localization predominantly in cytoplasm, using glassy carbon electrodes.

Ferrocene-Based Compounds with Antimalaria/Anticancer Activity

This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity.

Current scenario of ferrocene-containing hybrids for antimalarial activity.

Synthesis, antimicrobial and photoelectric potency of new ferrocene-based congeners

A set of quinoline, cholesterol, and monopyranoside tagged ferrocene-chalcone-1,2,3-triazole triads was prepared via simple CuAAC. Physico and photoelectric consideration of these conjugates



Antitumor activities of ferrocene compounds

Data on the antitumor activities of ferrocene compounds and the results concerning the mechanisms of their action published between 1995 and 2010 are discussed. The biomedical aspects of the study of

Synthesis of novel ferrocenyl sugars and their antimalarial activities.

A [3]ferrocenophane polyphenol showing a remarkable antiproliferative activity on breast and prostate cancer cell lines.

Two new ferrocenophane compounds are presented, one of which has an antiproliferative effect seven times stronger than the corresponding noncyclic species, with IC50 values of 90 and 94 nM on hormone-independent MDA-MB-231 breast and PC-3 prostate cancer cell lines, respectively.

On the medicinal chemistry of ferrocene

Organometallic chemistry and biochemistry have been merged in the last two decades into a new field: bioorganometallic chemistry. This new research area was devoted to the synthesis of new

Ferrocene Functionalized Endocrine Modulators as Anticancer Agents

Ferrocene has proven to be a fascinating substituent due to its vast potential for oncology and an original mechanism to explain the unusual behaviour of these bioorganometallic species is proposed, involving ROS production and bio-oxidation.