Application of cytochrome P450 drug interaction screening in drug discovery.

  title={Application of cytochrome P450 drug interaction screening in drug discovery.},
  author={Robert S. Foti and Larry C. Wienkers and Jan L. Wahlstrom},
  journal={Combinatorial chemistry & high throughput screening},
  volume={13 2},
Advances in drug interaction screening have resulted in reduced compound attrition rates due to unfavorable CYP-mediated drug interactions in clinical trials and improved patient safety. A major driver for the success in predicting drug interactions is a better understanding of the biological, chemical or mechanical factors that can impact the prediction of drug interactions in vitro. The enzyme source, probe substrate, accessory proteins and pharmacogenetics can all have profound effects upon… CONTINUE READING

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