Application of continuous twin screw granulation for the metformin hydrochloride extended release formulation.


This study focuses on evaluating the potential of transferring from a batch process to continuous process for manufacturing of the extended release formulation. Metformin hydrochloride (HCl) was used in the model formulation which was intended to contain the high amount of hydrophilic drug. The effects of barrel temperature, binder type, powder feed rate… (More)
DOI: 10.1016/j.ijpharm.2017.07.019


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