Application of computational methods for structural and functional characterization of mutants of GALT enzyme

@inproceedings{Marabotti2012ApplicationOC,
  title={Application of computational methods for structural and functional characterization of mutants of GALT enzyme},
  author={Anna Marabotti and Angelo Facchiano and Luciano Milanesi and Manshu Tang and Kent Lai},
  year={2012}
}
Motivations Galactose-1-phosphate uridylyltransferase (GALT) catalyses the conversion of galactose-1-phosphate to UDP-galactose, a key step in the galactose metabolism. Deficiency of GALT activity in humans caused by mutations in the GALT gene are associated to a rare genetic disease called Classic Galactosemia. To date, more than 180 mutations are known on… CONTINUE READING