Application of combinatorial chemistry science on modern drug discovery.

@article{Kennedy2008ApplicationOC,
  title={Application of combinatorial chemistry science on modern drug discovery.},
  author={J. Kennedy and Lyndsey Williams and T. M. Bridges and R. N. Daniels and D. Weaver and C. Lindsley},
  journal={Journal of combinatorial chemistry},
  year={2008},
  volume={10 3},
  pages={
          345-54
        }
}
  • J. Kennedy, Lyndsey Williams, +3 authors C. Lindsley
  • Published 2008
  • Chemistry, Medicine
  • Journal of combinatorial chemistry
  • The science that established combinatorial chemistry as important new discipline in the 1980s and 1990s has re-emerged and infiltrated every sub-discipline within modern drug discovery and has profound impact. The application of combinatorial chemistry science has revolutioned high-throughput screening paradigms, chemical lead optimization, library purification, and post-purification sample handling, as well as in vitro and in vivo drug metabolism and pharmacokinetic assays. Although no longer… CONTINUE READING
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    References

    SHOWING 1-10 OF 51 REFERENCES
    Drug discovery today.
    • 791
    • PDF
    Drug Discovery Today: Technologies (2007) volume 4 issues 3/4.
    • S. Carney
    • Biology, Medicine
    • Drug discovery today. Technologies
    • 2007
    • 29
    Handbook of fluorous chemistry
    • 542
    Macromolecules
    • C. Tanford
    • Medicine
    • Protein science : a publication of the Protein Society
    • 1948
    • 4,409
    26) Macarron, R. Drug DiscoVery Today
    • 26) Macarron, R. Drug DiscoVery Today
    • 2006
    29) For information on BlueShift Isocyte, see: www.blueshiftbiotech. com
    • 29) For information on BlueShift Isocyte, see: www.blueshiftbiotech. com
    54) Warrington, B. H. Lab. Autom. Chem. Ind
    • 54) Warrington, B. H. Lab. Autom. Chem. Ind
    • 2002
    ACS Chem. Biol
    • ACS Chem. Biol
    • 2007