Application of combinatorial chemistry science on modern drug discovery.

@article{Kennedy2008ApplicationOC,
  title={Application of combinatorial chemistry science on modern drug discovery.},
  author={J. Phillip Kennedy and Lyndsey Williams and Thomas M. Bridges and R Nathan Daniels and David H. Weaver and Craig W Lindsley},
  journal={Journal of combinatorial chemistry},
  year={2008},
  volume={10 3},
  pages={
          345-54
        }
}
Drug discovery is a competitive discipline that requires constant innovation and refinement as a combination of market, patient, and regulatory concerns require that company’s balance their novel, clinically unvalidated molecular targets with validated targets (KO, ASO, siRNA) because the attrition rate for novel targets is substantial. The dramatic consolidations across the pharmaceutical industry in recent years clearly point to the complexities of modern drug discovery. With the high… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

ACS Chem. Biol

  • C W Lindsley, D Weaver, P J Conn, L Marnett
  • ACS Chem. Biol
  • 2007

Bioorg. Med. Chem. Lett

  • Z Zhao, D D Wisnoski, +13 authors C W Lindsley
  • Bioorg. Med. Chem. Lett
  • 2007

Drug DiscoVery DeV

  • S V Ley, I R Baxendale, D A Longbottom, R M Meyers
  • Drug DiscoVery DeV
  • 2007

Int. J. Pep. Res. Ther

  • Int. J. Pep. Res. Ther
  • 2007

J. Comb. Chem

  • L Pisani, H Prokopcova, J M Kremsner, C O Kappe
  • J. Comb. Chem
  • 2007

J. Org. Chem

  • M Zhang, D L Flynn, P R Hanson
  • J. Org. Chem
  • 2007

Khojasteh-Bakht, S. C. Drug Metabol. Lett

  • J S Halladay, S Wong, S M Jaffer, A K Sinhababu
  • Khojasteh-Bakht, S. C. Drug Metabol. Lett
  • 2007

Macromolecules

  • R B Breitenkamp, Z Ou, K Breitenkamp, M Muthukumar, T Emrick
  • Macromolecules
  • 2007

Nippon Yakurigaku Zasshi

  • T Ueki
  • Nippon Yakurigaku Zasshi
  • 2007

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