Application of central composite design in the optimisation of thermal desorption parameters for the trace level determination of the chemical warfare agent chloropicrin.

Abstract

A quantitative trace-level thermal desorption gas chromatography mass spectrometry method was developed for chloropicrin CCl3NO2 using central composite design. Factors influencing the thermal decomposition were elucidated and optimum conditions for maximum response deduced. Four factors were investigated: desorption time, desorption temperature, valve… (More)

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@article{Muir2002ApplicationOC, title={Application of central composite design in the optimisation of thermal desorption parameters for the trace level determination of the chemical warfare agent chloropicrin.}, author={Bob Muir and Wendy A Carrick and David B. Cooper}, journal={The Analyst}, year={2002}, volume={127 9}, pages={1198-202} }