Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience.

@article{Subrammaniyan2011ApplicationOA,
  title={Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience.},
  author={R Subrammaniyan and Joseph Amalorpavanathan and Rajendran Shankar and M. Rajkumar and Subramani Baskar and Sadananda Rao Manjunath and Rajappa Senthilkumar and Palanisamy Murugan and V Srinivasan and Samuel J. K. Abraham},
  journal={Cytotherapy},
  year={2011},
  volume={13 8},
  pages={
          993-9
        }
}
BACKGROUND AIMS Previous clinical studies have reported that the injection of bone marrow (BM)-derived mononuclear cells (MNC) results in improvement in symptoms and healing of ulcers in patients with critical limb ischemia (CLI) up to stage IV of Fontaine's classification. However, most patients with Fontaine stage IV CLI limbs had to undergo amputation even after stem cell therapy. We report on six patients, who had poorly controlled diabetes with extensive ulceration and gangrene of limbs… 

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