Application of an intragenic genomic probe to genetic counselling for haemophilia B in the west of Scotland.

@article{Connor1985ApplicationOA,
  title={Application of an intragenic genomic probe to genetic counselling for haemophilia B in the west of Scotland.},
  author={J. Michael Connor and Andrew Pettigrew and Ian M. Hann and Charles D. Forbes and Gordon D. O. Lowe and N. A. Affara},
  journal={Journal of medical genetics},
  year={1985},
  volume={22 6},
  pages={441-6}
}
Total ascertainment revealed 28 families with haemophilia B in the west of Scotland (prevalence 1/26 870 males). In 12 of these families more than one person was affected and 26 living obligate carriers were identified and tested. Of these, 42% were heterozygous for a DNA polymorphism recognised by a factor IX genomic probe. No recombination was observed in… CONTINUE READING