Application of an in vitro assay for serum thymidine kinase: Results on viral disease and malignancies in humans

@article{Gronowitz1984ApplicationOA,
  title={Application of an in vitro assay for serum thymidine kinase: Results on viral disease and malignancies in humans},
  author={J. Simon Gronowitz and Clas F. R. K{\"a}llander and Hans Diderholm and Hans Hagberg and U. Pettersson},
  journal={International Journal of Cancer},
  year={1984},
  volume={33}
}
An improved method for the detection of deoxythymidine kinase (TK) in human sera is reported. The method which utilizes 125I‐iododeoxyuridine (IdUrd) as a substrate was used to measure TK in sera from patients with different diseases. Sera collected during the acute stage of infectious mononucleosis were found to contain elevated levels of TK, in most cases 10–40 times the normal value. The serum TK activity disappeared gradually and reached a normal level within 4 weeks. Sera from patients… 

Changes of serum thymidine kinase in children with acute leukemia.

TLDR
The study showed that the elevation of TK serum levels during follow-up was a helpful marker for the recognition of an early stage of relapse and in some cases occurred as early as one month before the appearance of clinical signs.

Diagnostic implications of the molecular forms and levels of serum thymidine kinase 1 in different canine malignancies

TLDR
Overall, the results demonstrate that TK1 protein assays provide valuable diagnostic information in a variety of canine malignancies.

The Clinical Significance of Thymidine Kinase 1 Measurement in Serum of Breast Cancer Patients Using Anti-TK1 Antibody

TLDR
In conclusion, the anti-TK1 antibody could be a good marker for monitoring the response of breast cancer patients to therapy.

Serum Thymidine Kinase (TK) Evaluation in HIV Infection

TLDR
Serum TK was elevated from the beginning of the HIV infection, the seropositive stage, and more markedly afterwards during the course of the infection, with a close correlation with the stage.

Serum deoxythymidine kinase gives prognostic information in chronic lymphocytic leukemia

TLDR
It is concluded that S‐TK could be used as a prognostic marker for the individual CLL patient and seems to be useful for longitudinal follow‐up studies of disease status, both in indolent disease and in progressive disease during treatment.

Serum Thymidine Kinase Activity as a Useful Marker for Bovine Leukosis

TLDR
Results indicate that serum TK activity may be a marker for bovine leukosis, and the sensitivity and specificity of measuring serum Tk activity as a diagnostic tool for Bovine Leukosis was 95.0% and 95.9%, respectively.

Molecular properties of serum thymidine kinase 1 and use of the canine enzyme in disease monitoring

TLDR
Investigating the molecular characteristics of canine thymidine kinase 1 and utilizing several anti-TK1 antibodies to a better understanding its role in disease prognostics, risk assessment, and monitoring of cancer development revealed that serum TK1 activity was elevated in 41% of bitches with pyometra, and thus TK 1 determinations may be clinically valuable also in some non-neoplastic diseases.

Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.

TLDR
Detailed multiparameter longitudinal investigations of 5 patients and ongoing studies of 70 other patients suggest that STK is a more reliable marker of progressive disease than either SB2M, LI, M-protein or CD10 positive lymphocytes.

Serum deoxythymidine kinase as a progressive marker of hematological malignancy.

TLDR
The results suggest that high levels of s-dTK in hematological malignancy may reflect the extent of disease and that this activity may be derived from proliferating leukemic cells.
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TLDR
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TLDR
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TLDR
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TLDR
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