Application of an improved method for the recombinant k 39 enzyme-linked immunosorbent assay to detect visceral leishmaniasis disease and infection in Bangladesh.

@article{Kurkjian2005ApplicationOA,
  title={Application of an improved method for the recombinant k 39 enzyme-linked immunosorbent assay to detect visceral leishmaniasis disease and infection in Bangladesh.},
  author={Katie M. Kurkjian and Louise Elaine Vaz and Rashidul Haque and C C{\^e}tre-Sossah and Shamim Akhter and Sylvain Le Roy and Francis J. Steurer and Joseph Amann and Manir Ali and Reshmi Chowdhury and Yukiko Wagatsuma and Jan Williamson and Shawana Crawford and Robert F. Breiman and James H. Maguire and Caryn Bern and W Evan Secor},
  journal={Clinical and diagnostic laboratory immunology},
  year={2005},
  volume={12 12},
  pages={1410-5}
}
Several serology-based immunoassays are used to diagnose visceral leishmaniasis (VL), a chronic protozoan parasitic disease caused by the Leishmania donovani complex. These tests are primarily designed to diagnose the most severe clinical form of VL, known as kala-azar. However, leishmanial infection is frequently asymptomatic and may manifest only as a positive serologic response or positive leishmanin skin test. We modified a previously described enzyme-linked immunosorbent assay (ELISA) that… CONTINUE READING

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