Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries

@article{Slade2004ApplicationOA,
  title={Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries},
  author={Rachel M. Slade and Ma Phillips and Joel G. Berger},
  journal={Molecular Diversity},
  year={2004},
  volume={4},
  pages={215-219}
}
Resin-bound triphenylphosphine was coupledto 4-fluoro-3-nitrobenzyl bromide, and2-alkylthiobenzimidazoles were synthesized onresin in 4 steps using standard chemistries. Cleavage of the compounds from the resin wasachieved with 10% NaOH in MeOH to leave amethyl group at the attachment point. A totalof 47 amines and 40 electrophiles wereevaluated, defining the scope of the reactions,culminating in the synthesis of an 80-membertest library of high purity as determined by HPLC. 
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