Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building

@inproceedings{Sherer2012ApplicationOA,
  title={Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building},
  author={Eric A. Sherer and Mark E. Sale and Bruce G. Pollock and Chandra Prakash Belani and Merrill J. Egorin and Percy S. Ivy and Jeffrey A. Lieberman and Stephen B. Manuck and Stephen R. Marder and Matthew F. Muldoon and Howard I. Scher and David B. Solit and Robert R Bies},
  booktitle={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2012}
}
A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and model fitness evaluation to a single-objective, hybrid genetic algorithm for global optimization of the… CONTINUE READING