Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill.

@article{Mohamed2012ApplicationOA,
  title={Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill.},
  author={Ami F Mohamed and Ilias Karaiskos and Diamantis Plachouras and Matti Karvanen and Konstantinos Pontikis and Britt Jansson and Evangelos D Papadomichelakis and Anastasia Antoniadou and Helen Giamarellou and Apostolos Armaganidis and Otto Cars and Lena E. Friberg},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 8},
  pages={4241-9}
}
A previous pharmacokinetic study on dosing of colistin methanesulfonate (CMS) at 240 mg (3 million units [MU]) every 8 h indicated that colistin has a long half-life, resulting in insufficient concentrations for the first 12 to 48 h after initiation of treatment. A loading dose would therefore be beneficial. The aim of this study was to evaluate CMS and colistin pharmacokinetics following a 480-mg (6-MU) loading dose in critically ill patients and to explore the bacterial kill following the use… CONTINUE READING
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