Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA.

@article{Nakamura2012ApplicationOA,
  title={Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA.},
  author={Tomomi Nakamura and Naoko Sueoka-Aragane and Kentaro Iwanaga and Akemi Sato and Kazutoshi Komiya and Naomi Kobayashi and Shinichiro Hayashi and Toshiya Hosomi and Mitsuharu Hirai and Eisaburo Sueoka and Shinya Kimura},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2012},
  volume={7 9},
  pages={1369-81}
}
INTRODUCTION : Detection of epidermal growth factor receptor (EGFR) mutations is indispensable to determine an appropriate lung cancer treatment. Although retreatment often prolongs survival, how to select the appropriate population for retreatment has not been clarified. METHODS : We used novel methods to identify EGFR mutations: wild inhibiting polymerase chain reaction (PCR) and quenched probe system (WIP-QP) for exon 19 deletions and mutation-biased PCR and quenched probe system for L858R… CONTINUE READING
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