Application of a high-throughput, parallel HPLC system for quantitative chiral analysis of pantoprazole.

@article{Wang2015ApplicationOA,
  title={Application of a high-throughput, parallel HPLC system for quantitative chiral analysis of pantoprazole.},
  author={Hao Wang and Yantong Sun and Yan Yang and Wei Guo and Mi Zheng and Weiping Zhang and J. Paul Fawcett and Jingkai Gu},
  journal={Bioanalysis},
  year={2015},
  volume={7 23},
  pages={2981-90}
}
BACKGROUND Chromatographic separation of enantiomers is considered a task in analytical chemistry particularly for high sample throughput. This paper describes a high-throughput parallel HPLC-MS/MS method for the determination of pantoprazole enantiomers. RESULTS Baseline separation of pantoprazole enantiomers was achieved on a Chiralcel OZ-RH column in a run time of 4.5 min. Assays for enantiomers were linear with satisfactory intra- and inter-day precision and accuracy. The assay was… CONTINUE READING
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