Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans.

@article{Abraham2008ApplicationOA,
  title={Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans.},
  author={Vivek C Abraham and Danli L Towne and Jeffrey F. Waring and Usha Warrior and David W. Burns},
  journal={Journal of biomolecular screening},
  year={2008},
  volume={13 6},
  pages={527-37}
}
Prioritization of compounds based on human hepatotoxicity potential is currently a key unmet need in drug discovery, as it can become a major problem for several lead compounds in later stages of the drug discovery pipeline. The authors report the validation and implementation of a high-content multiparametric cytotoxicity assay based on simultaneous measurement of 8 key cell health indicators associated with nuclear morphology, plasma membrane integrity, mitochondrial function, and cell… CONTINUE READING