Application of a fiber-matrix model to transport in renal tubules

@article{Fraser1989ApplicationOA,
  title={Application of a fiber-matrix model to transport in renal tubules},
  author={W. D. Fraser and Andrew D. Baines},
  journal={The Journal of General Physiology},
  year={1989},
  volume={94},
  pages={863 - 879}
}
The effects of tight junction structure on water and solute fluxes across proximal tubular epithelium were examined with fiber-matrix equations previously derived by Curry and Michel (1980. Microvascular Research. 20:96-99). Using plausible estimates of tight junction fiber length and width the model predicts solute (Ps) and water permeability (Lp) coefficients that agree with the measured values. When fiber-matrix and pore models were compared for physiologically relevant ranges of matrix void… CONTINUE READING

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