Application of a convective-dispersion model to predict in vivo hepatic clearance from in vitro measurements utilizing cryopreserved human hepatocytes.

Abstract

Growing interest in the prediction of in vivo pharmacokinetic data from purely in vitro data has grown into a process known as the in vitro-in vivo correlation (IVIC). IVIC can be used to determine the viability of new chemical entities in the early drug development phases, leading to a reduction of resource spending by many large pharmaceutical companies… (More)

Topics

Cite this paper

@article{Niro2003ApplicationOA, title={Application of a convective-dispersion model to predict in vivo hepatic clearance from in vitro measurements utilizing cryopreserved human hepatocytes.}, author={Ryan Niro and James Byers and Ronald L Fournier and Kenneth A. Bachmann}, journal={Current drug metabolism}, year={2003}, volume={4 5}, pages={357-69} }