Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.

@article{Ballard2016ApplicationOA,
  title={Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.},
  author={T Eric Ballard and Shuai Wang and Loretta M. Cox and Mark A Moen and Stacy Krzyzewski and Okechukwu Ukairo and R Scott Obach},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2016},
  volume={44 2},
  pages={172-9}
}
Laboratory animal models are the industry standard for preclinical risk assessment of drug candidates. Thus, it is important that these species possess profiles of drug metabolites that are similar to those anticipated in human, since metabolites also could be responsible for biologic activities or unanticipated toxicity. Under most circumstances, preclinical species reflect human in vivo metabolites well; however, there have been several notable exceptions, and understanding and predicting… CONTINUE READING
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