Application of a High-Resolution Mass-Spectrometry-Based DNA Adductomics Approach for Identification of DNA Adducts in Complex Mixtures

@inproceedings{Balbo2014ApplicationOA,
  title={Application of a High-Resolution Mass-Spectrometry-Based
DNA Adductomics Approach for Identification of DNA Adducts in Complex
Mixtures},
  author={Silvia Balbo and Stephen S Hecht and Pramod Upadhyaya and Peter W Villalta},
  booktitle={Analytical chemistry},
  year={2014}
}
Liquid chromatography coupled with mass spectrometry (LC-MS) is the method of choice for analysis of covalent modification of DNA. DNA adductomics is an extension of this approach allowing for the screening for both known and unknown DNA adducts. In the research reported here, a new high-resolution/accurate mass MS(n) methodology has been developed representing an important advance for the investigation of in vivo biological samples and for the assessment of DNA damage from various human… CONTINUE READING