Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.

@article{Knudsen2016ApplicationOA,
  title={Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.},
  author={Beatrice S. Knudsen and Hyung L. Kim and Nicholas George Erho and Heesun Shin and Mohammed Alshalalfa and Lucia Lam and Imelda Tenggara and Karen Chadwich and Theodorus H van der Kwast and Neil E. Fleshner and Elai Davicioni and Peter R. Carroll and Matthew R. Cooperberg and June Maylin Chan and Jeffry P. Simko},
  journal={The Journal of molecular diagnostics : JMD},
  year={2016},
  volume={18 3},
  pages={395-406}
}
Molecular and genomic analysis of microscopic quantities of tumor from formalin-fixed, paraffin-embedded biopsy specimens has many unique challenges. Herein, we evaluated the feasibility of obtaining transcriptome-wide RNA expression to measure prognostic classifiers in diagnostic prostate needle core biopsy specimens. One-hundred fifty-eight samples from diagnostic needle core biopsy specimens (BX) and radical prostatectomies (RPs) were collected from 33 patients at three hospitals; each… CONTINUE READING
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