Application of X-ray microanalysis to the study of drug uptake in cell culture.

@article{Reasor1990ApplicationOX,
  title={Application of X-ray microanalysis to the study of drug uptake in cell culture.},
  author={Mark J. Reasor and Ping -Cheung Lee and R. Gary Kirk},
  journal={Experimental and molecular pathology},
  year={1990},
  volume={53 1},
  pages={64-71}
}
X-ray microanalysis has been used previously to study the accumulation of iodine in alveolar macrophages of rats treated with the iodinated drug, amiodarone. Due to metabolism of the drug in vivo, primarily to desethylamiodarone, it was not possible to identify the source of the iodine signal. In the present study we have utilized primary cell cultures of alveolar macrophages to study the intracellular accumulation of each of these drug species in vitro. Neither drug is metabolized by these… CONTINUE READING