Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies

@inproceedings{Daurio2011ApplicationOT,
  title={Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies},
  author={Dominick Daurio and C{\'e}sar Julio Bustacara Medina and Robert E Saw and Karthik Nagapudi and Fernando Alvarez-N{\'u}{\~n}ez},
  booktitle={Pharmaceutics},
  year={2011}
}
The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, and Theophylline-Citric acid, were selected for the study. The parameters of the extrusion process that… CONTINUE READING