Application of Structure Equation Modeling for Inferring a Serial Transcriptional Regulation in Yeast

@article{Aburatani2011ApplicationOS,
  title={Application of Structure Equation Modeling for Inferring a Serial Transcriptional Regulation in Yeast},
  author={S. Aburatani},
  journal={Gene Regulation and Systems Biology},
  year={2011},
  volume={5},
  pages={75 - 88}
}
  • S. Aburatani
  • Published 2011
  • Medicine
  • Gene Regulation and Systems Biology
Revealing the gene regulatory systems among DNA and proteins in living cells is one of the central aims of systems biology. In this study, I used Structural Equation Modeling (SEM) in combination with stepwise factor analysis to infer the protein-DNA interactions for gene expression control from only gene expression profiles, in the absence of protein information. I applied my approach to infer the causalities within the well-studied serial transcriptional regulation composed of GAL-related… Expand
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