Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements

@article{Jobanputra2005ApplicationOR,
  title={Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements},
  author={Vaidehi Jobanputra and Jonathan Sebat and Jennifer Troge and Wendy K Chung and Kwame Anyane-Yeboa and Michael Wigler and Dorothy Warburton},
  journal={Genetics in Medicine},
  year={2005},
  volume={7},
  pages={111-118}
}
Purpose: To demonstrate the accuracy and sensitivity of Representational Oligonucleotide Microarray Analysis (ROMA) to describe copy number changes in patients with chromosomal abnormalities.Methods: ROMA was performed using BglII digested DNA from two cases with cytogenetically detected deletions and one case with an unbalanced terminal rearrangement detected only by subtelomeric FISH. Hybridization was to an 85,000-probe oligonucleotide microarray, providing an average resolution of 35 kb… CONTINUE READING
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Gene copy number polymorphism is common in the human population and widely distributed in the genome

  • J Sebat, T Muthuswamy, J Troge, J Alexander, J Young, P Lundin
  • Science
  • 2004

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