Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity.

@article{Trepakova2007ApplicationOP,
  title={Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity.},
  author={Elena S Trepakova and Manish G Malik and John P. Imredy and Jacob R Penniman and Spencer J Dech and Joseph J. Salata},
  journal={Assay and drug development technologies},
  year={2007},
  volume={5 5},
  pages={617-27}
}
A cardiac safety concern for QT prolongation and potential for pro-arrhythmia exists due to inhibition of the cardiac slowly activating delayed rectifier potassium current, I(Ks). Selective inhibitors of I Ks have been shown to prolong the QT interval in animal models. On the other hand, I Ks has been considered as a target for anti-arrhythmic therapy due to certain biophysical and pharmacological properties and its expression pattern in the heart. Consequently, we have developed a method… CONTINUE READING