Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.

Abstract

First pass metabolism in the intestinal mucosa is a determinant of oral bioavailability of CYP3A substrates and so the prediction of intestinal availability (Fg) of potential drug candidates is important. Although intestinal metabolism can be modeled in commercial physiologically based pharmacokinetic (PBPK) software tools, a thorough evaluation of… (More)
DOI: 10.1016/j.ejps.2012.06.013

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@article{Heikkinen2012ApplicationOP, title={Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.}, author={Aki T. Heikkinen and Guillaume Baneyx and Antonello Caruso and Neil John Parrott}, journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, year={2012}, volume={47 2}, pages={375-86} }