Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin.

  title={Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin.},
  author={Martina Jonsson and Marika Jestoi and Alexis V. Nathanail and Ulla-Maija Kokkonen and Marjukka Anttila and Pertti Koivisto and Pirkko T Karhunen and Kimmo Peltonen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
Moniliformin is a Fusarium mycotoxin highly prevalent in grains and grain-based products worldwide. In this study, the acute oral toxicity of moniliformin was assessed in Sprague-Dawley male rats according to OECD Guideline 423 with a single-dose exposure. Clinical observations and histopathological changes were recorded together with the excretion of moniliformin via urine and feces, utilizing a novel liquid chromatography-mass spectrometry method. According to our study, moniliformin is… CONTINUE READING
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