Application of Multivariate Strategies to the Classification of Pharmaceutical Excipient Manufacturers Based on Near-Infrared (NIR) Spectra.

@article{Wang2015ApplicationOM,
  title={Application of Multivariate Strategies to the Classification of Pharmaceutical Excipient Manufacturers Based on Near-Infrared (NIR) Spectra.},
  author={Ting Wang and Ahmed Khair Ibrahim and Alan R. Potts and Stephen W. Hoag},
  journal={Applied spectroscopy},
  year={2015},
  volume={69 11},
  pages={1257-70}
}
Using partial least square discriminate analysis (PLSDA), we studied the spectroscopic differences between the commonly used filler-binder microcrystalline cellulose (MCC) from five manufactures. These samples had subtle differences in the chemical and physical properties, which are often the cause of differences in excipient performance. Studying these differences allowed us to build and validate a model to classify five manufacturers of MCC using near-infrared (NIR) spectra. The sample… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 53 references

‘Understanding and Predicting Pharmaceutical Excipient Variability and Performance Using Spectroscopic and Multivariate Analysis Approaches’

T. Wang
[Ph.D. Dissertation]. Baltimore: University of Maryland, • 2014

‘The Creation of an Excipient Properties Database to Support Quality by Design (QbD) Formulation Development’

T. Wang, K. M. Alston, +6 authors S. W. Hoag
Am. Pharm. Rev. • 2013

Westerhuis . ‘ ‘ DoubleCheck : Validation of Diagnostic Statistics for PLSDA Models in Metabolomics Studies

E. J. J. van Velzen J. A. Westerhuis, H. C. J. Hoefsloot
Metabolomics • 2012

nska, E

E. Szyma
Saccenti, A.K. Smilde, J.A. Westerhuis. ‘‘DoubleCheck: Validation of Diagnostic Statistics for PLS-DA Models in Metabolomics Studies’’. Metabolomics. • 2012

A

T. Łojewski, P. Miśkowiec, M. Missori
Luba nska, L.M. Proniewicz, J. Łojewska. ‘‘FTIR and UV/Vis as Methods for Evaluation of Oxidative Degradation of Model Paper: DFT Approach for Carbonyl Vibrations’’. Carbohydr. Polym. • 2010

FTIR and UV / Vis as Methods for Evaluation of Oxidative Degradation of Model Paper : DFT Approach for Carbonyl Vibrations

M. Missori, A. Luba
Carbohydr . Polym . • 2010

‘Cellulose, Microcrystalline’

A. Guy
R.C. Rowe, P.J. Sheskey, M.E. Quinn, editors. Handbook of Pharmaceutical Excipients. Weinheim, Germany: Wiley-VCH, 2002. Pp. 179-211. Pharmaceutical Press and American Pharmacists Association. • 2009

Similar Papers

Loading similar papers…