Application of Multigene Panel Sequencing in Patients with Prolonged Rate-corrected QT Interval and No Pathogenic Variants Detected in KCNQ1, KCNH2, and SCN5A

@article{Seo2018ApplicationOM,
  title={Application of Multigene Panel Sequencing in Patients with Prolonged Rate-corrected QT Interval and No Pathogenic Variants Detected in KCNQ1, KCNH2, and SCN5A},
  author={Soo Hyun Seo and So Yeon Kim and Sung Im Cho and Hyunwoong Park and Seungjun Lee and Jong Moon Choi and Man Jin Kim and Jee-Soo Lee and Kyung Jin Ahn and Mi Kyoung Song and Eun Jung Bae and Sung Sup Park and Moon-Woo Seong},
  journal={Annals of Laboratory Medicine},
  year={2018},
  volume={38},
  pages={54 - 58}
}
Long QT syndrome (LQTS) is an inherited cardiac disease characterized by a prolonged heart rate-corrected QT (QTc) interval. We investigated the genetic causes in patients with prolonged QTc intervals who were negative for pathogenic variants in three major LQTS-related genes (KCNQ1, KCNH2, and SCN5A). Molecular genetic testing was performed using a panel including 13 LQTS-related genes and 67 additional genes implicated in other cardiac diseases. Overall, putative genetic causes of prolonged… 
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