Application of LC-TOF MS to analysis of hemoglobin acetaldehyde adducts in alcohol detoxification patients.

@article{Toennes2010ApplicationOL,
  title={Application of LC-TOF MS to analysis of hemoglobin acetaldehyde adducts in alcohol detoxification patients.},
  author={Stefan W Toennes and Moritz G. Wagner and Gerold F. Kauert},
  journal={Analytical and bioanalytical chemistry},
  year={2010},
  volume={398 2},
  pages={769-77}
}
Acetaldehyde adducts of hemoglobin have been regarded as potential biochemical markers of alcohol exposure. In this study a novel sensitive method using liquid chromatography coupled to time-of-flight mass spectrometry (LC-TOF MS) has been used to investigate changes in adduct levels in alcohol detoxification patients. Hemoglobin and authentic blood samples from 66 adults with an alcohol-dependence syndrome and from 12 children were analyzed for acetaldehyde modifications with and without… CONTINUE READING