Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides.

@article{Lin2007ApplicationOL,
  title={Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides.},
  author={Zhongping John Lin and Wenkui Li and Guowei Dai},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2007},
  volume={44 2},
  pages={330-41}
}
Therapeutic oligonucleotides (OGNs) have been studied extensively in the recent years as novel agents designed to selectively and specifically inhibit target gene expression in cell culture, in animal disease models and in human. This review summarizes applications of liquid chromatography coupled with mass spectrometry or tandem mass spectrometry (LC-MS or LC-MS/MS) for quantitative analysis of therapeutic OGNs and characterization of their metabolism in vitro and in vivo described in the… CONTINUE READING

From This Paper

Topics from this paper.
20 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…