Application of Intense Pulsed Light in the Treatment of Dermatologic Disease: A Systematic Review

  title={Application of Intense Pulsed Light in the Treatment of Dermatologic Disease: A Systematic Review},
  author={Heidi Wat and Douglas C Wu and Jaggi Rao and Mitchel P. Goldman},
  journal={Dermatologic Surgery},
BACKGROUND The Food and Drug Administration (FDA) has approved intense pulsed light (IPL) devices for the treatment of a variety of benign pigmentary and vascular lesions, but the range of disease amenable to IPL treatment continues to expand, and there are no evidence-based clinical guidelines for its use in FDA-approved and off-label indications. [] Key MethodEVIDENCE REVIEW A literature search of the CENTRAL (1991 to May 6, 2013), EMBASE (1974 to May 6, 2013), and MEDLINE in-process and nonindexed…

Figures from this paper

A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma

A meta-analysis showed that IPL-based combination therapy for melasma can effectively reduce the MASI score and result in higher satisfaction among patients, indicating an effective method for treatment of the condition.

Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction.

The body of evidence for this outcome was of very low certainty, so it is uncertain about the effect of IPL on dry eye symptoms, but there were no relevant combinable data for any of the other secondary outcomes, thus the effect on clinical parameters relevant to dry eye disease are currently unclear.

Intense Pulsed Light Therapy In The Treatment Of Meibomian Gland Dysfunction: Current Perspectives

This review summarizes the clinical outcomes of IPL therapy in MGD patients pointing out its potential role in the therapeutic algorithm of the disease.

The Efficacy of Intense Pulsed Light as a Treatment for Benign Pigmented Lesions on the Dorsal Hand

Objective analysis, along with clinician and subject assessments, showed an improvement in the appearance of benign pigmented lesions in the treated area after 3 IPL treatments.

Intense Pulsed Light: Friend or Foe? Molecular Evidence to Clarify Doubts.

Data highlight the deleterious impact of IPL on skin phenotype, which justifies the need for more experimental studies in order to increase the understanding of the IPL long-term safety.

Effects of intense pulsed light in microstomia in patients with systemic sclerosis: A pilot study

In conclusion, IPL can improve the inter-ridge distance between the lips in patients with microstomia due to systemic sclerosis but does not affect theInter-incisal distance, which is also dependent on the mobility of the mandibular joints.

Intense pulsed light therapy: A promising complementary treatment for dry eye disease

Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction

IPL-MGX ameliorated symptoms and improved the condition of the tear film in patients with refractory MGD and is therefore a promising treatment option for this disorder.



New topical photodynamic therapy for management of primary axillary hyperhidrosis: a single-blinded, placebo-controlled study

Photodynamic therapy using eosin gel, which is photoactivated by IPL, is a noninvasive, safe, and effective method for management of primary axillary hyperhidrosis with no risk of multiple frequent injections and is not time-consuming.

Effective Treatment of Rosacea Using Intense Pulsed Light Systems

It is demonstrated that IPL treatment of facial rosacea is effective in obtaining clearance of 77.8%, with minimal side effects, and that treatment effects are maintained.

Histopathologic Changes Induced by Intense Pulsed Light in the Treatment of Poikiloderma of Civatte

Intense pulsed light treatment of PC induced a more‐homogeneous distribution of melanin and increased nonfragmented elastic fibers, collagen density, and intensity, which were related to clinical improvement.

Topical Photodynamic Therapy Using Intense Pulsed Light for Treatment of Actinic Keratosis: Clinical and Histopathologic Evaluation

Intense pulsed light is potentially an effective light source for PDT, however, the determination of complete remission in actinic keratosis requires caution, and long-term follow-up or histologic confirmation may be required.

Efficacy and Safety of Intense Pulsed Light in Treatment of Melasma in Chinese Patients

IPL treatment is a good option for patients with melasma and patients with the epidermal-type melasma responded better to treatment than the mixed type, and adverse actions were minimal.

Efficacy of photodynamic therapy with topical 5‐aminolevulinic acid using intense pulsed light for Bowen’s disease

ALA‐PDT with IPL as a light source is well tolerated by patients and is beneficial for treating Bowen’s disease, and it appeared that the affected areas showed improvement in all the patients.

Photopneumatic therapy for the treatment of acne.

Moderate reduction in acne lesion counts and global clinical improvement was seen in the majority of patients and photopneumatic therapy is a safe and effective treatment for acne vulgaris.

Intense pulsed light source for treatment of facial telangiectasias

An IPL with dual mode filtering is efficient and safe for treatment of facial telangiectasias and no long-term adverse effects such as scars or pigmentary disturbances occurred.

Intense pulsed light for the treatment of Rosacea and Telangiectasias

The use of IPL at specified parameters provides optimal therapy for the treatment of rosacea and 80% of patients had reduction in redness, 78% of customers reported reduced flushing and improved skin texture, and 72% noted fewer acneiform breakouts.

Treatment of Inflammatory Facial Acne Vulgaris with Intense Pulsed Light and Short Contact of Topical 5‐Aminolevulinic Acid: A Pilot Study

  • Prapawan Choawawanich
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2006
Short contact of topical ALA and IPL or IPL alone showed some beneficial effect in treatment of inflammatory facial acne; however, degree of improvement was better and remained longer with the combined regimen.