Application of Hansen Solubility Parameters to predict drug-nail interactions, which can assist the design of nail medicines.

@article{Hossin2016ApplicationOH,
  title={Application of Hansen Solubility Parameters to predict drug-nail interactions, which can assist the design of nail medicines.},
  author={B Hossin and Khalida Rizi and Sudaxshina Murdan},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2016},
  volume={102},
  pages={32-40}
}
We hypothesised that Hansen Solubility Parameters (HSPs) can be used to predict drug-nail affinities. Our aims were to: (i) determine the HSPs (δD, δP, δH) of the nail plate, the hoof membrane (a model for the nail plate), and of the drugs terbinafine HCl, amorolfine HCl, ciclopirox olamine and efinaconazole, by measuring their swelling/solubility in organic liquids, (ii) predict nail-drug interactions by comparing drug and nail HSPs, and (iii) evaluate the accuracy of these predictions using… CONTINUE READING