Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors.

@article{Ajmani2012ApplicationOG,
  title={Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors.},
  author={Subhash Ajmani and Sudhir A. Kulkarni},
  journal={Molecular informatics},
  year={2012},
  volume={31 6-7},
  pages={473-90}
}
Many literature reports suggest that drugs against multiple targets may overcome many limitations of single targets and achieve a more effective and safer control of the disease. However, design of multitarget drugs presents a great challenge. The present study demonstrates application of a novel Group based QSAR (GQSAR) method to assist in lead optimization of multikinase (PDGFR-beta, FGFR-1 and SRC) and scaffold hopping of multiserotonin target (serotonin receptor 1A and serotonin transporter… CONTINUE READING
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