Application of Drug Nanocrystal Technologies on Oral Drug Delivery of Poorly Soluble Drugs

@article{Gao2012ApplicationOD,
  title={Application of Drug Nanocrystal Technologies on Oral Drug Delivery of Poorly Soluble Drugs},
  author={Lei Gao and Guiyang Liu and Jianli Ma and Xiaoqing Wang and Liang Zhou and Xiang Li and Fang Wang},
  journal={Pharmaceutical Research},
  year={2012},
  volume={30},
  pages={307-324}
}
The limited solubility and dissolution rate exhibited by poorly soluble drugs is major challenges in the pharmaceutical process. Following oral administration, the poorly soluble drugs generally show a low and erratic bioavailability which may lead to therapeutic failure. Pure drug nanocrystals, generated by “bottom up” or “top down” technologies, facilitate a significant improvement on dissolution behavior of poorly soluble drugs due to their enormous surface area, which in turn lead to… 
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