Application of Computational Systems Biology to Explore Environmental Toxicity Hazards

  title={Application of Computational Systems Biology to Explore Environmental Toxicity Hazards},
  author={Karine Audouze and Philippe Grandjean},
  journal={Environmental Health Perspectives},
  pages={1754 - 1759}
Background: Computer-based modeling is part of a new approach to predictive toxicology. Objectives: We investigated the usefulness of an integrated computational systems biology approach in a case study involving the isomers and metabolites of the pesticide dichlorodiphenyltrichloroethane (DDT) to ascertain their possible links to relevant adverse effects. Methods: We extracted chemical–protein association networks for each DDT isomer and its metabolites using ChemProt, a disease chemical… 

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