Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: superior performance of the IGK assays compared to IGH for suboptimal specimens.

@article{Halldrsdttir2007ApplicationOB,
  title={Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: superior performance of the IGK assays compared to IGH for suboptimal specimens.},
  author={Anna Margr{\'e}t Halld{\'o}rsd{\'o}ttir and Barbara A. Zehnbauer and W Richard Burack},
  journal={Leukemia & lymphoma},
  year={2007},
  volume={48 7},
  pages={
          1338-43
        }
}
The BIOMED-2 PCR-based immunoglobulin gene rearrangement assays have quickly become the most commonly used laboratory method for detection of B-cell clonality. Therefore, the reliability of these assays under various conditions has become increasingly important. When studying paired cases of follicular lymphoma (FL) from individual patients, we used these assays to assess clonality in 40 formalin-fixed paraffin-embedded (FFPE) specimens from 19 patients diagnosed with FL. The assays of IGH… CONTINUE READING
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