• Corpus ID: 51800281

Application of Anticancer Agents from Fermentation of Soy Using Bifidobacterium and Lactobacillus Sp., A Review

@inproceedings{Rani2014ApplicationOA,
  title={Application of Anticancer Agents from Fermentation of Soy Using Bifidobacterium and Lactobacillus Sp., A Review},
  author={V. Usha Rani and B V Pradeep},
  year={2014}
}

• V. U. Rani, B. Pradeep
• Published 2014
• Biology

Cancer drug development presently focuses on rational drugs that have the ability to cross the cell membrane and bind to a specific enzyme or receptor. Current research in cancer treatment aimed at finding new prognostic targets for therapy, the goal of research is to find natural substances that modulate the regulatory signals such as cell cycle, growth factor and cell death. Soybean (Glycine max. L.) a common part of diet possess a high content of proteins and important source of phytoestrogen. Recent study states that phytoestrogen posses pharmacological, toxicological and mechanical properties for various chronic diseases such as cancer, osteoporosis and atherosclerosis. The isoflavones exerts as glycoside linkage which limits the absorption, therefore hydrolysis of soy milk with probiotic bacteria cleave the glycosidic linkage by -galactosidase thereby increasing the concentration and activity of bioactive molecules. The major isoflavonoids found in soybean are genistein and daidzein, that resembles structure of estrogen and they can interact with the estrogen receptor. Thus fermenting soy increases the concentration of isoflavones (genistein and daidizien) which exhibits its anticancer activity.