Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

Abstract

We have developed 3D-tumoroids and tumor slice in vitro culture systems from surgical tumor specimens derived from patients with colorectal cancer (CRC) or lung cancer to evaluate immune cell populations infiltrating cultured tissues. The system incorporates patient's peripherally and tumor-derived immune cells into tumoroid in vitro cultures to evaluate… (More)
DOI: 10.18632/oncotarget.19965

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Cite this paper

@inproceedings{Finnberg2017ApplicationO3, title={Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures}, author={Niklas K. Finnberg and Prashanth Gokare and Avital Lev and Sergei I. Grivennikov and A W Macfarlane and Kerry S. Campbell and Ryan M. Winters and Karen Kaputa and Jeffrey M. Farma and Abbas El-Sayed Abbas and Luigi Grasso and Nicholas C. Nicolaides and Wafik S El-Deiry}, booktitle={Oncotarget}, year={2017} }