Application of 2-D DIGE to formalin-fixed, paraffin-embedded tissues.

@article{Tanca2011ApplicationO2,
  title={Application of 2-D DIGE to formalin-fixed, paraffin-embedded tissues.},
  author={Alessandro Tanca and Daniela Pagnozzi and Giovanni Falchi and Roberto Tonelli and Stefano Rocca and Tonina Roggio and Sergio Uzzau and Maria Filippa Addis},
  journal={Proteomics},
  year={2011},
  volume={11 5},
  pages={1005-11}
}
The ability to investigate the proteome of formalin-fixed, paraffin-embedded (FFPE) tissues can be considered a major recent achievement in the field of clinical proteomics. However, gel-based approaches to the investigation of FFPE tissue proteomes have lagged behind, mainly because of insufficient quality of full-length protein extracts. Here, the 2-D DIGE technology was investigated for applicability to FFPE proteins, for internal reproducibility among replicate FFPE extracts, and for… CONTINUE READING
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