Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography

@article{ukowski1986ApplicationO,
  title={Application of $\alpha$- and $\beta$-cyclodextrin and heptakis(2,6-di-O-methyl)-$\beta$-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography},
  author={J. Żukowski and D. Sybilska and J. Bojarşki},
  journal={Journal of Chromatography A},
  year={1986},
  volume={364},
  pages={225-232}
}
Abstract Using LiChrosorb RP-18 as the stationary phase, systematic studies were performed on the changes in the capacity factors of a series of hydantoin and barbituric acid derivatives (including some therapeutically useful drugs) with variation in the concentrations of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin in the mobile phase.It has been found that both β-cyclodextrin and its dimethyl derivative exhibit enantioselectivities towards hydantoins and barbiturates… Expand
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